Description
MOTS-C
For Research Use Only | Not for Human or Veterinary Use
Description:
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. In preclinical laboratory research, MOTS-c has been extensively investigated for its role as a mitochondrial-encoded signaling molecule that regulates metabolic homeostasis, AMPK activation, and folate-methionine cycle dynamics. The peptide’s unique origin as a mitochondrial genome-encoded bioactive factor distinguishes it from nuclear-encoded peptides and positions it as a key research tool for studying retrograde mitochondrial signaling, cellular energy sensing, and metabolic stress responses.
Scientific Specifications:
- Peptide Name: MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c)
- Type: Mitochondria-Derived Peptide (MDP)
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: ~2174.6 g/mol
- CAS Number: 1627580-64-6
- PubChem CID: 121231475
- Form: Lyophilized powder
- Storage: Store dry in a cool, dark environment (2°C to 8°C)
Research Context:
MOTS-c is commonly studied for its potential effects on:
- AMPK activation and downstream metabolic pathway regulation in cellular energy sensing
- Folate-methionine cycle modulation and one-carbon metabolism dynamics
- Mitochondrial retrograde signaling and nuclear gene expression regulation
- Glucose uptake and insulin sensitivity pathways in skeletal muscle models
- Cellular stress resistance and exercise-mimetic signaling in aging research models
- Mitochondria-derived peptide biology and inter-organelle communication
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
What is MOTS-C?+
MOTS-C is a synthetic peptide (a 16-amino-acid peptide). ezPeps supplies it as a laboratory reference compound intended strictly for in-vitro and laboratory research use only.
Is ezPeps MOTS-C intended for human use?+
No. All ezPeps products are sold strictly for laboratory and research use only. They are not intended for human or veterinary use, consumption, or any clinical or diagnostic application.
What purity is ezPeps MOTS-C, and how is it verified?+
Every batch is analyzed by third-party HPLC and confirmed to 99%+ verified purity. A batch-specific Certificate of Analysis (COA) is available in our COA Library so you can review the results for the exact lot you receive.
What form does it ship in, and how should it be stored?+
It ships as a lyophilized (freeze-dried) powder in a sealed vial. Store vials in a cool, dark place; refrigeration or freezing is recommended for long-term storage. Handle according to standard laboratory protocols.
How quickly does ezPeps ship?+
Orders placed before our daily cutoff ship the same day, with domestic US delivery. Every order includes tracking.
Does ezPeps provide a Certificate of Analysis?+
Yes. Each product is backed by a third-party COA accessible through our COA Library and via the QR code on the product, so purity and identity are independently documented.
What is your guarantee?+
ezPeps offers a 30-day money-back guarantee. See our Return and Refund Policy for full details, or contact our support team if you are not satisfied.
New to sourcing research materials? Read our guide: How to Choose a Research Peptide Supplier (and How to Read a COA).
