Description
N-ACETYL SELANK AMIDATE
For Research Use Only | Not for Human or Veterinary Use
Description:
N-Acetyl Selank Amidate is a doubly end-capped analogue of Selank, the synthetic heptapeptide tuftsin analogue. Two modifications distinguish it from the parent peptide: the N-terminus is acetylated and the C-terminus is amidated. Both caps remove a charged terminus that exopeptidases recognise, and terminal capping of this kind is studied as a route to greater resistance to aminopeptidase and carboxypeptidase degradation and to altered membrane permeability. The underlying Thr-Lys-Pro-Arg-Pro-Gly-Pro sequence, and therefore the pharmacology under investigation, is shared with Selank; what is being studied here is the effect of the end-capping on stability and exposure rather than a different target.
Scientific Specifications:
- Peptide Name: N-Acetyl Selank Amidate
- Type: End-Capped Synthetic Heptapeptide (Selank Analogue)
- Sequence: Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂ (acetylated N-terminus, amidated C-terminus)
- Parent Peptide: Selank (TKPRPGP), C₃₃H₅₇N₁₁O₉, 751.89 g/mol, CAS 129954-34-3
- Modifications: N-terminal acetylation (+42.01 Da) and C-terminal amidation (-0.98 Da)
- Form: Lyophilized powder
- Storage: Store dry in a cool, dark environment (2°C to 8°C)
Research Context:
N-Acetyl Selank Amidate is commonly studied for its potential effects on:
- GABAergic neurotransmission modulation and anxiolytic-like behavioral paradigms
- Terminal capping and resistance to aminopeptidase and carboxypeptidase degradation
- Peptide half-life, metabolic stability and exposure relative to unmodified Selank
- Tuftsin-related immunomodulatory signaling
- BDNF expression and monoamine turnover in neurobehavioral research models
- Comparative pharmacology with Selank at matched sequence
Related Product:
For the unmodified parent peptide, see Selank.
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
