Description
VIP
For Research Use Only | Not for Human or Veterinary Use
Description:
VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily, originally isolated from porcine intestinal extracts. In preclinical laboratory research, VIP is extensively investigated for its activity at VPAC1 and VPAC2 receptors (class II G protein-coupled receptors), mediating cAMP-dependent signaling in a wide range of tissues including the gastrointestinal tract, central and peripheral nervous system, immune cells, and vascular smooth muscle. VIP functions as both a neurotransmitter and neuromodulator and serves as a fundamental research tool in neuroimmunology, gastrointestinal physiology, circadian biology, and pulmonary function studies.
Scientific Specifications:
- Peptide Name: VIP (Vasoactive Intestinal Peptide)
- Type: 28-Amino Acid Neuropeptide (Glucagon/Secretin Superfamily)
- Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
- Molecular Formula: C₁₄₇H₂₃₇N₄₃O₄₃S
- Molecular Weight: 3325.7 g/mol
- CAS Number: 40077-57-4
- PubChem CID: 53314964
- Form: Lyophilized powder
- Storage: Store dry in a cool, dark environment (2°C to 8°C)
Research Context:
VIP is commonly studied for its potential effects on:
- VPAC1 and VPAC2 receptor binding kinetics and cAMP-dependent signal transduction
- Gastrointestinal smooth muscle relaxation and secretomotor function regulation
- Anti-inflammatory and immunomodulatory signaling in macrophage and T-cell models
- Circadian rhythm regulation via suprachiasmatic nucleus (SCN) neuronal synchronization
- Pulmonary vasodilation and bronchodilatory pathway research in airway biology
- Neuroprotective signaling and glial cell modulation in neuroinflammation models
Intended Use:
This product is intended strictly for laboratory research applications only by qualified scientific personnel. It is not approved for human or animal consumption, and may not be used in foods, drugs, supplements, cosmetics, or diagnostics.
Legal Disclaimer:
The statements provided and this compound have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of any disease. Use is restricted to qualified researchers operating in certified laboratory environments.
Terms of Sale:
By purchasing this product, the buyer affirms they are a qualified researcher or institutional purchaser, fully responsible for proper handling, storage, and legal compliance.
